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PeterDonnelly_2005G-_统计数据是如何迷惑陪审团的_
As other speakers have said, it's a rather daunting experience -- a particularly daunting experience -- to be speaking in front of this audience. 正如一些演讲者所说 在这里的观众面前演讲 是一次令人畏缩的经历--相当令人恐慌
daunting:adj.令人生畏的:令人胆怯的:v.使胆怯:使失去信心;(daunt的现在分词) particularly:adv.特别地,独特地;详细地,具体地;明确地,细致地;
But unlike the other speakers, I'm not going to tell you about the mysteries of the universe, or the wonders of evolution , or the really clever, innovative ways people are attacking the major inequalities in our world. 不过与其他演讲者不同 我不会给大家讲 宇宙的迷团 也不会讲进化的奥妙 抑或是人们用来对抗世界上主要的不平等现象的 那些着实非常奇妙新颖的办法
evolution:n.演变;进化;发展;渐进; innovative:adj.革新的,创新的; inequalities:n.[数]不等式;不均等,不平衡;不平坦(inequality的复数形式);
Or even the challenges of nation-states in the modern global economy . 更不会讲现代全球经济下国家之间的挑战
nation-states:n.民族国家;单一民族国家(nation-state的复数形式); global:adj.全球的;总体的;球形的; economy:n.经济;节约;理财;
My brief, as you've just heard, is to tell you about statistics -- and, to be more precise , to tell you some exciting things about statistics. 就像你们刚才听到的 概括来说 我讲的内容是统计学-- 更确切地说 是一些统计学中很有趣的事情
statistics:n.统计数字;统计资料;统计学;(statistic的复数) precise:adj.准确的;确切的;精确的;明确的;
And that's -- 而这--
(Laughter) （笑）
- that's rather more challenging than all the speakers before me and all the ones coming after me. -相对所有在我之前以及之后的演讲者而言 具有空前绝后的挑战性
(Laughter) （笑）
One of my senior colleagues told me, when I was a youngster in this profession , rather proudly , that statisticians were people who liked figures but didn't have the personality skills to become accountants . 当我在统计学这个领域还是新人的时候 一个资深同事相当自豪地告诉我 统计学家是那些喜欢数字 但性格上不适合做会计的人
senior:adj.大;级别(或地位)高的;成人的;高级水平的;n.上级;上司;较…年长的人; colleagues:n.同事;同行(colleague的复数); youngster:n.年轻人;少年; profession:n.行业,职业;业内人士;同行; proudly:傲慢地 statisticians:n.统计学家,统计员; personality:n.性格;个性;人格;魅力;气质;名人;特色; accountants:n.会计;会计师;(accountant的复数)
(Laughter) （笑）
And there's another in-joke among statisticians, and that's, "How do you tell the introverted statistician from the extroverted statistician?" 还有一个统计学的笑话 “怎样看出统计学家是内向还是外向呢？”
in-joke:n.小范围笑话,内部笑话,只有圈内人才能领悟的笑话; introverted:adj.内向的;v.使...内向(introvert的过去分词形式);使内翻; extroverted:adj.性格外向的;外向性的;喜社交的;
To which the answer is, "The extroverted statistician's the one who looks at the other person's shoes." 答案就是 “外向的统计学家会看别人的鞋”
(Laughter) （笑）
But I want to tell you something useful -- and here it is, so concentrate now. 不过其实我想讲一些有用的--所以请注意
concentrate:n.浓缩物;v.聚精会神;集中(注意力);使…集中(或集合、聚集);(使)浓缩;
This evening, there's a reception in the University's Museum of Natural History . 今晚在学校的自然历史博物馆里有一个招待会
Natural History:n.自然史;
And it's a wonderful setting, as I hope you'll find, and a great icon to the best of the Victorian tradition. 希望你能发现 这是一个绝妙的场合 也是维多利亚优秀传统中的表现
It's very unlikely -- in this special setting, and this collection of people -- but you might just find yourself talking to someone you'd rather wish that you weren't. 在这样的场合 这样的人群中 虽然有点不大可能 但你也许仍然发现你在跟一些你并不想聊天的人交谈
unlikely:adj.不大可能发生的;非心目中的;非想象的;难以相信的;
So here's what you do. 这时候你就可以这么做
When they say to you, "What do you do?" -- you say, "I'm a statistician." 当他们问:“你的工作是？”--你就说:“我是统计学家”
(Laughter) （笑）
Well, except they've been pre-warned now, and they'll know you're making it up. 除非他们事先得到提醒 知道这是你编的
And then one of two things will happen. 一般出现的情形都不过以下两种
They'll either discover their long-lost cousin in the other corner of the room and run over and talk to them. 他们会突然在屋子另一角发现了失散多年的表亲 然后赶去跟他们说话
long-lost:adj.遗失了很长时间的;
Or they'll suddenly become parched and/or hungry -- and often both -- and sprint off for a drink and some food. 或者他们会突然很渴或者很饿--通常是饥渴交迫-- 然后奔向食物和饮料
parched:adj.焦的;炎热的;炒过的;干透的;v.烘干;使极渴(parch的过去分词); sprint:vi.冲刺,全速跑;n.冲刺;短跑;vt.全速奔跑;
And you'll be left in peace to talk to the person you really want to talk to. 这是你就能一个人静下来 跟你想聊天的人交谈
It's one of the challenges in our profession to try and explain what we do. 解释我们到底是做什么的 是我们这个领域的一个挑战
We're not top on people's lists for dinner party guests and conversations and so on. 我们并不是晚宴的贵宾 也不是理想的交谈对象
dinner party:晚宴;
And it's something I've never really found a good way of doing. 对此我也一直没能找到什么好的解决办法
But my wife -- who was then my girlfriend -- managed it much better than I've ever been able to. 但我的妻子--当时是我的女朋友 在这件事上就比我出色的多
Many years ago, when we first started going out, she was working for the BBC in Britain, and I was, at that stage, working in America. 多年前 那时我们刚开始约会 她在英国BBC工作 而我当时在美国
I was coming back to visit her. 我回英国看她的时候
She told this to one of her colleagues, who said, "Well, what does your boyfriend do?" 她跟一个同事说起这事 那个同事问:“你男朋友是做什么的？”
Sarah thought quite hard about the things I'd explained -- and she concentrated , in those days, on listening. 她苦苦思索着我刚才解释过的工作 于是那段时间她一直是一个专心的倾听者
concentrated:adj.决心要做的; v.集中(注意力); (concentrate的过去式和过去分词)
(Laughter) （笑）
Don't tell her I said that. 别告诉她我跟说过这事
And she was thinking about the work I did developing mathematical models for understanding evolution and modern genetics . 她当时想 我的工作是建立数模 来加深对进化和现代基因学的了解
mathematical:adj.数学的,数学上的;精确的; genetics:n.遗传学;
So when her colleague said, "What does he do?" 所以当同事问:“他是干什么的？”
She paused and said, "He models things." 她就停顿一下 然后说:“他做模型。”
(Laughter) （笑）
Well, her colleague suddenly got much more interested than I had any right to expect and went on and said, "What does he model?" 当然 她的同事立即就对我产生了出乎我意料的兴趣 并继续问:“他做什么模型？”
Well, Sarah thought a little bit more about my work and said, " Genes ." 然后 萨拉又想了想我的工作 然后答:“基因。”
Genes:n.基因;(gene的复数)
(Laughter) （笑）
'"He models genes." “他建立基因模型。”
That is my first love, and that's what I'll tell you a little bit about. 这就是我的初恋 题外话了
What I want to do more generally is to get you thinking about the place of uncertainty and randomness and chance in our world, and how we react to that, and how well we do or don't think about it. 总的来说 我要给大家讲一些 不确定性、随机性和概率在生活中的影响 我们对此的反应是怎样的 以及我们了解他们的程度
generally:adv.通常;普遍地,一般地; uncertainty:n.不确定,不可靠; randomness:n.随意;无安排;不可测性; react:v.起反应;回应;(对食物等)有不良反应,过敏;起化学反应;
So you've had a pretty easy time up till now -- a few laughs, and all that kind of thing -- in the talks to date. 到现在为止大家听得都很轻松 到现在为止都是听听笑笑
You've got to think, and I'm going to ask you some questions. 现在大家要开始思考了 我会提几个问题
So here's the scene for the first question I'm going to ask you. 下面这个场景就是我开始问第一个问题
Can you imagine tossing a coin successively ? 想象连续掷硬币的情形
tossing:v.扔,抛,掷;甩;(使)摇摆,挥动,颠簸;(toss的现在分词) successively:adv.相继地;接连着地;
And for some reason -- which shall remain rather vague -- we're interested in a particular pattern. 由于某种原因--我就暂时不做过多的解释了-- 我们很喜欢某种特定的情形
vague:adj.模糊的;含糊的;不明确的;暧昧的;
Here's one -- a head, followed by a tail, followed by a tail. 比如这个--正面、反面、正面
So suppose we toss a coin repeatedly . 假设我们连续掷硬币
suppose:v.推断:假定:假设:设想: repeatedly:adv.反复地;再三地;屡次地;
Then the pattern, head-tail-tail, that we've suddenly become fixated with happens here. 然后我们设定这样一个情形 正反反
fixated:adj.念念不忘的;稳固关系的;v.使固定下来;注视(fixate的过去分词);
And you can count: one, two, three, four, five, six, seven, eight, nine, 10 -- it happens after the 10th toss. 数着掷十次:一 二 三 四 五 六 七 八 九 十 然后看结果怎么样
So you might think there are more interesting things to do, but humor me for the moment. 你可能觉得还有更有趣的事可以做 不过这次先迁就我一下
humor:n.幽默;心情;情绪;脾气;v.迎合;迁就;
Imagine this half of the audience each get out coins, and they toss them until they first see the pattern head-tail-tail. 假设这半边观众都拿出硬币开始投掷 直到他们看到正反反现象为止
The first time they do it, maybe it happens after the 10th toss, as here. 第一回投硬币 也许十次以后才能看到
The second time, maybe it's after the fourth toss. 第二回 也许第四次就能看到
The next time, after the 15th toss. 再下一回 也许比15次还多
So you do that lots and lots of times, and you average those numbers. 做过很多遍这个实验后 将每遍的次数平均
That's what I want this side to think about. 这就是我想让这半边思考的情况
The other half of the audience doesn't like head-tail-tail -- they think, for deep cultural reasons, that's boring -- and they're much more interested in a different pattern -- head-tail-head. 那半边观众不喜欢正反反 出于某些深刻的文化因素 他们觉得这很无聊-- 他们跟更喜欢另一种情形--正反正
other half:n.另一半(指配偶或男友,女友); cultural:adj.与文化有关的;文化的;与艺术、文学、音乐等有关的; boring:adj.无聊的;令人厌烦的;n.钻孔;v.使厌烦;钻孔;(bore的现在分词)
So, on this side, you get out your coins, and you toss and toss and toss. 所以 这半边的观众拿出硬币 反复投掷
And you count the number of times until the pattern head-tail-head appears and you average them. OK? 然后记下看到正反正情形出现时掷硬币的次数 然后将所有的次数平均
So on this side, you've got a number -- you've done it lots of times, so you get it accurately -- which is the average number of tosses until head-tail-tail. 那么 这半边的观众得出了一个平均数 因为做了很多次 所以这个数字是准确的 就是正反反情形出现时投掷硬币次数的平均
accurately:adv.精确地,准确地; tosses:v.扔,抛,掷;(使)摇摆,挥动,颠簸;(toss的第三人称单数)
On this side, you've got a number -- the average number of tosses until head-tail-head. 而这半边的观众 大家也得出了一个数字--正反正情形的平均
So here's a deep mathematical fact -- if you've got two numbers, one of three things must be true. 那么就有了这样一个数学问题 两个数之间只能有三种情形
Either they're the same, or this one's bigger than this one, or this one's bigger than that one. 他们或者相等 或者这个比那个大 或者那个比这个大
So what's going on here? 那么在我们这两种情形下这两个数相比会怎样呢
So you've all got to think about this, and you've all got to vote -- and we're not moving on. 大家来思考一下 然后投个票 现在给大家一些时间
And I don't want to end up in the two-minute silence to give you more time to think about it, until everyone's expressed a view. OK. 不过我不想因为给大家更多的时间思考直到每个人都立场明确 而最后以两分钟沉默告终
expressed:v.表示;表达;显而易见;不言自明;(express的过去分词和过去式)
So what you want to do is compare the average number of tosses until we first see head-tail-head with the average number of tosses until we first see head-tail-tail. 所以你们要做的只是比较这两种情形下 平均数的大小
compare:v.比较;对比;n.比较;
Who thinks that A is true -- that, on average, it'll take longer to see head-tail-head than head-tail-tail? 哪些认为A是对的-- 即 平均来看 出现正反正的情形要晚于正反反情形？
Who thinks that B is true -- that on average, they're the same? 哪些认为B是对的--即 平均来看次数相同？
Who thinks that C is true -- that, on average, it'll take less time to see head-tail-head than head-tail-tail? 哪些认为C是对的--即 平均来看 出现正反正情形的次数 要少于正反反的情形？
OK, who hasn't voted yet? Because that's really naughty -- I said you had to. 好 谁没有投票？ 那真是很调皮--我说过你们要选择一个
naughty:adj.顽皮的;淘气的;不听话的;
(Laughter) （笑）
OK. So most people think B is true. 好的 那么大多数人认为B是正确的
And you might be relieved to know even rather distinguished mathematicians think that. 也许当听到甚至非常优秀的数学家也是这么想的 你会放下心来
relieved:adj.释然的; v.缓解; distinguished:adj.尊贵的; v.区分; mathematicians:n.[数]数学家(mathematician的复数形式);
It's not. A is true here. B不正确 答案是A
It takes longer, on average. 实际上 平均起来
In fact, the average number of tosses till head-tail-head is 10 and the average number of tosses until head-tail-tail is eight. 正反正情形下掷硬币的次数是10次 而正反反情形的次数是8次
How could that be? 怎么会这样呢
Anything different about the two patterns? 这两种情形有什么不同吗
There is. Head-tail-head overlaps itself. 二者的确不同 正反正情形会自我重叠
overlaps:n.重叠部分(overlap的复数形式);v.重叠;重复(overlap的第三人称单数);
If you went head-tail-head-tail-head, you can cunningly get two occurrences of the pattern in only five tosses. 如果你掷出正-反-正-反-正 你能在这五次中 看到两次正反正的情形
cunningly:adv.巧妙地,狡猾地; occurrences:n.发生的事情;发生;出现;(occurrence的复数)
You can't do that with head-tail-tail. 而这在正反反的情形下无法实现
That turns out to be important. 这一点变得很重要
There are two ways of thinking about this. 有两种方法可以来想这个问题
I'll give you one of them. 我提供其中之一
So imagine -- let's suppose we're doing it. 假设我们正在进行这个实验
On this side -- remember, you're excited about head-tail-tail, you're excited about head-tail-head. 这半边观众--记住 你们希望看到正反反 而你们希望看到正反正
We start tossing a coin, and we get a head -- and you start sitting on the edge of your seat because something great and wonderful, or awesome , might be about to happen. 我们开始投硬币 第一次是正 大家都开始暗自激动 因为一个美妙绝伦的事情要发生了
on the edge of:adv.几乎;濒于;在…边缘; awesome:adj.令人敬畏的;使人畏惧的;可怕的;极好的;
The next toss is a tail -- you get really excited. 第二次是反--大家都很激动
The champagne 's on ice just next to you, you've got the glasses chilled to celebrate. 手边的香槟已经冰好 大家都拿着杯子开始准备庆祝
champagne:n.香槟酒;香槟酒色; chilled:adj.冷却了的; v.使很冷; (chill的过去分词和过去式)
You're waiting with bated breath for the final toss. 大家都屏气凝神观望最后一掷
bated:adj.除去的;减去的;v.压制(bate的过去分词);
And if it comes down a head, that's great. 如果是正 那么非常好
You're done, and you celebrate. 你们完了 而你们可以庆祝了
If it's a tail -- well, rather disappointedly, you put the glasses away and put the champagne back. 如果这是反--那么有些遗憾 你们要把杯子移开 然后把香槟放回去
And you keep tossing, to wait for the next head, to get excited. 接着掷硬币 等着下一个正 然后开始激动
On this side, there's a different experience. 而这半边则完全不同
It's the same for the first two parts of the sequence . 这个序列中前两步都是相同的
sequence:n.顺序; v.按顺序排列;
You're a little bit excited with the first head -- you get rather more excited with the next tail. 大家因第一个是正有点兴奋 当第二个是反的时候 变得更加激动
Then you toss the coin. 然后再掷硬币
If it's a tail, you crack open the champagne. 如果是反 你们就可以打开香槟了
crack:v.使破裂;打开;变声;n.裂缝;声变;噼啪声;adj.最好的;高明的;
If it's a head you're disappointed, but you're still a third of the way to your pattern again. 如果是正 你们会感到失望 但你们仍旧已经完成了这个模式的三分之一
And that's an informal way of presenting it -- that's why there's a difference. 这就是一种不大正式的解释--这就是出现不同的原因
informal:adj.非正式的;不拘礼节的;通俗的;日常使用的;
Another way of thinking about it -- if we tossed a coin eight million times, then we'd expect a million head-tail-heads and a million head-tail-tails -- but the head-tail-heads could occur in clumps . 另外一种思考的方法就是-- 如果我们掷八百万次硬币 我们可能会预计有一百万正反正情形 和一百万次正反反情形的出现--但正反正的情形可能接连出现
tossed:v.扔,抛,掷;甩;(使)摇摆,挥动,颠簸;(toss的过去分词和过去式) clumps:块;
So if you want to put a million things down amongst eight million positions and you can have some of them overlapping , the clumps will be further apart. 所以如果你想在八百万个位置中得到一百万个固定的模式 可能会有一些是重叠的 重叠的部分会很长
amongst:prep.在…之中;在…当中(等于among); overlapping:v.(物体)部分重叠,交叠;使部分重叠;(overlap的现在分词)
It's another way of getting the intuition . 这就是另外一种思考方法
intuition:n.直觉;直觉力;直觉的知识;
What's the point I want to make? 那么这说明什么问题呢？
It's a very, very simple example, an easily stated question in probability , which every -- you're in good company -- everybody gets wrong. 这是一个非常简单的例子 一个很简单明了的问题-- 有很多人跟你们一样--这个问题几乎没有人答对
probability:n.可能性;机率;[数]或然率;
This is my little diversion into my real passion , which is genetics. 这是一个小小的题外话 我很想讲的 是基因学
diversion:n.转移;消遣;分散注意力; passion:n.激情;热情;酷爱;盛怒;
There's a connection between head-tail-heads and head-tail-tails in genetics, and it's the following. 在基因学中 正反正和正反反两种情形间存在某种联系 这个联系是这样的
When you toss a coin, you get a sequence of heads and tails. 掷硬币的时候 你会得到一个正和反组成的序列
When you look at DNA, there's a sequence of not two things -- heads and tails -- but four letters -- A's, G's, C's and T's. 而当观察DNA时 会发现这不是两个元素组成的序列--正反正-- 而是四个字母--A G C T
And there are little chemical scissors , called restriction enzymes which cut DNA whenever they see particular patterns. 有一些小小的化学剪刀 叫做限制性内切酶 当它们遇到特定的情形时 就会剪断DNA
chemical:n.化学制品,化学药品;adj.化学的; scissors:n.剪刀;v.剪断;删除;(scissor的第三人称单数和复数) restriction:n.限制;约束;束缚; enzymes:n.[生化]酶(enzyme的复数);酶类,酵素;
And they're an enormously useful tool in modern molecular biology . 在现代分子生物学中它们是非常有用的工具
enormously:adv.巨大地,庞大地;非常地,在极大程度上; molecular:adj.[化学]分子的;由分子组成的; biology:n.(一个地区全部的)生物;生物学;
And instead of asking the question, "How long until I see a head-tail-head?" -- you can ask, "How big will the chunks be when I use a restriction enzyme which cuts whenever it sees G-A-A-G, for example? 在基因学中 我们不问“什么时候能看到正反正的情形？” 你可以问 比如说 “如果用限制性内切酶来剪断任何它遇到的GAAG排列 剪下来的基因部分会有多大?”
chunks:n.厚块;大块;相当大的量;组块;(chunk的复数)
How long will those chunks be?" 那些基因部分会有多长？
That's a rather trivial connection between probability and genetics. 这是概率和基因之间的一个相当细微的联系
trivial:adj.不重要的,琐碎的;琐细的;
There's a much deeper connection, which I don't have time to go into and that is that modern genetics is a really exciting area of science. 他们之间还有一个更深的联系 这里我没有时间多讲 那就是 现代基因学是一个很令人激动的科学领域
And we'll hear some talks later in the conference specifically about that. 以后我们可能会在某些大会的演讲中听到这个部分
conference:n.会议;研讨会;商讨会;体育协会(或联合会) specifically:adv.特别地;明确地;
But it turns out that unlocking the secrets in the information generated by modern experimental technologies , a key part of that has to do with fairly sophisticated -- 但是若把现代实验技术中发现的秘密公开, 关键就是那必须与一些相当复杂的--
unlocking:v.(用钥匙)开…的锁;发现;揭示;揭开;(unlock的现在分词) generated:v.产生;引起;(generate的过去式和过去分词) experimental:adj.实验的;根据实验的;试验性的; technologies:n.技术;科技(technology的复数); fairly:adv.相当地;公平地;简直; sophisticated:adj.复杂的;老练的;见多识广的;水平高的;
you'll be relieved to know that I do something useful in my day job, rather more sophisticated than the head-tail-head story -- but quite sophisticated computer modelings and mathematical modelings and modern statistical techniques . 当听到我的工作是多有用的时候你们会倍感释然 比正反正的试验要复杂地多-- 但是相当复杂的计算机建模 数学建模 以及现代统计技术
statistical:adj.统计的;统计学的; techniques:n.技巧;技艺;工艺;技术;(technique的复数)
And I will give you two little snippets -- two examples -- of projects we're involved in in my group in Oxford, both of which I think are rather exciting. 我会举在牛津我们团队正在研究的项目中 的两个小例子 我认为这两个例子都很有趣
snippets:n.片段(snippet的复数形式);小片; involved:adj.有关的; v.涉及; (involve的过去式和过去分词)
You know about the Human Genome Project. 大家都了解人类基因组计划
Genome:n.基因组;染色体组;
That was a project which aimed to read one copy of the human genome. 那是一个项目 目的在于构建人类基因组遗传图谱
The natural thing to do after you've done that -- and that's what this project, the International HapMap Project, which is a collaboration between labs in five or six different countries. 当完成那个项目后 下一步自然是-- --就是这个计划 国际人类基因组单体型图计划 目前有五六个不同个国家的实验室在合作研究
collaboration:n.合作;勾结;通敌; labs:n.实验室;实验大楼;(lab的复数)
Think of the Human Genome Project as learning what we've got in common, and the HapMap Project is trying to understand where there are differences between different people. 把人类基因遗传图谱看做是对我们共同点的了解 而国际人类基因组单体型图计划就是试着了解 人类之间的不同
Why do we care about that? 为什么要这么关注这些呢？
Well, there are lots of reasons. 这有很多原因
The most pressing one is that we want to understand how some differences make some people susceptible to one disease -- type-2 diabetes , for example -- 最紧迫的一个就是 我们想了解其中一些不同 是怎样让一些人容易患一种病的--比如说 二型糖尿病--
susceptible:adj.易受影响的;易感动的;容许…的;n.易得病的人; disease:n.病,[医]疾病;弊病;vt.传染;使…有病; diabetes:n.糖尿病;多尿症;
and other differences make people more susceptible to heart disease, or stroke , or autism and so on. 而另一些不同使人更容易得心脏病 或中风 自闭症等等其它病症
stroke:n.中风;笔画;钟声;抚摩;v.抚摩(动物的毛皮);轻抚;轻挪;轻触; autism:n.[心理][内科]孤独症;自我中心主义;
That's one big project. 这是一个宏大的项目
There's a second big project, recently funded by the Wellcome Trust in this country, involving very large studies -- thousands of individuals , with each of eight different diseases , 最近 英国威康信托基金会资助了一个项目 其规模仅次于上一个项目 它包括了很多大型的研究-- 成千上万的人各负责八种不同的疾病
recently:adv.最近;新近; funded:adj.提供资金的;v.提供资金;积存;提供资金偿付的本息;(fund的过去式); involving:v.包含;需要;牵涉;牵连;影响;(使)参加;(involve的现在分词) individuals:n.[经]个人;[生物]个体(individual的复数); diseases:n.[医]病(disease的复数);[医]疾病;[植保]病害;疾病种类;
common diseases like type-1 and type-2 diabetes, and coronary heart disease, bipolar disease and so on -- to try and understand the genetics. 有一些比较常见的疾病 比如一型糖尿病 二型糖尿病和冠心病 躁狂抑郁症等等--来试着了解基因
coronary:adj.冠的;冠状的;花冠的; bipolar:adj.有两极的,双极的;
To try and understand what it is about genetic differences that causes the diseases. 着这了解那些导致疾病的基因的不同之处
Why do we want to do that? 为什么我们想做这些呢？
Because we understand very little about most human diseases. 因为我们对大多数人类疾病都了解甚微
We don't know what causes them. 我们不知道病因是什么
And if we can get in at the bottom and understand the genetics, we'll have a window on the way the disease works. 如果我们从根本入手并了解基因 这边开启了一个通向疾病病理的窗口
And a whole new way about thinking about disease therapies and preventative treatment and so on. 也开辟了思考疾病治疗方法 和预防措施的新路径
therapies:n.治疗方法(therapy复数形式); preventative:n.预防法;预防物;adj.预防性的;防止的; treatment:n.治疗;疗法;对待;处理;讨论;
So that's, as I said , the little diversion on my main love. 所以 就像我之前说过的那样 这是我主要兴趣的一个小分支
as I said:正如我所说的
Back to some of the more mundane issues of thinking about uncertainty. 回到一些关于随机性的平凡的问题上来
mundane:adj.世俗的,平凡的;世界的,宇宙的; issues:n.重要议题;争论的问题;v.宣布;公布;发出;(issue的第三人称单数和复数)
Here's another quiz for you -- now suppose we've got a test for a disease which isn't infallible , but it's pretty good. 这是给你们的另一个测试-- 现在假设我们拿到了一个疾病的检测 这个检测并不是完全准确的 但准确性很高
quiz:n.小测验;知识竞赛;v.盘问;查问;询问; infallible:adj.绝对可靠的;绝无错误的;n.永远正确的人;绝无谬误的事物;
It gets it right 99 percent of the time. 这个检测的准确性高达99%
And I take one of you, or I take someone off the street, and I test them for the disease in question. 现在我让你们中的一个人 或从街上拉来一个人 然后检测他患病的几率
Let's suppose there's a test for HIV -- the virus that causes AIDS -- and the test says the person has the disease. 假设这是一个艾滋病毒的测试--一个导致艾滋病的病毒-- 而测试表明这个人患病
HIV:n.艾滋病病毒;
What's the chance that they do? 那么他患病的几率是多少呢
The test gets it right 99 percent of the time. 这个测试准确性是99%
So a natural answer is 99 percent. 所以自然而然会得出99%这个答案
Who likes that answer? 谁喜欢这个答案？
Come on -- everyone's got to get involved. 别这样--每个人都参与进来
Don't think you don't trust me anymore. 不要觉得你不再相信我了
(Laughter) （笑）
Well, you're right to be a bit skeptical , because that's not the answer. 不过 你们的怀疑是正确的 因为这不是正确答案
skeptical:adj.怀疑的;怀疑论的,不可知论的;
That's what you might think. 你们可能是这么想的
It's not the answer, and it's not because it's only part of the story. 这不是正确答案 并不是因为这只是故事的一部分
It actually depends on how common or how rare the disease is. 而实际上它取决于这种病是常见的还是罕见的
So let me try and illustrate that. 现在我来试着说明一下
illustrate:v.解释;加插图于;给(书等)做图表;表明…真实;
Here's a little caricature of a million individuals. 这个图代表一百万人
caricature:n.漫画;讽刺画;漫画手法;vt.画成漫画讽刺;
So let's think about a disease that affects -- it's pretty rare, it affects one person in 10,000. 我们来考虑一种疾病的感染率-- 它非常罕见 在一万人中仅一人患病
Amongst these million individuals, most of them are healthy and some of them will have the disease. 在这一百万人中 大部分人都是健康的 而一些人会患病
And in fact, if this is the prevalence of the disease, about 100 will have the disease and the rest won't. 实际上 如果这是疾病的流行程度 那么约一百人会患病而其余人不会
prevalence:n.流行;普遍;广泛;
So now suppose we test them all. 现在假设我们给所有人做了测试
What happens? 会出现什么情况呢
Well, amongst the 100 who do have the disease, the test will get it right 99 percent of the time, and 99 will test positive . 在100个患有该疾病的人中 这个测试会有99%的正确性 所以99个人会检测出患病
positive:adj.积极的;[数]正的,[医][化学]阳性的;确定的;n.正数;[摄]正片;
Amongst all these other people who don't have the disease, the test will get it right 99 percent of the time. 在那些没有患病的人中 这个测试仍然有99%的正确率
It'll only get it wrong one percent of the time. 只有1%是错误的
But there are so many of them that there'll be an enormous number of false positives . 但是没有患病的人太多了 所以错误的患病检测会非常多
positives:n.实在的事物;阳极板(positive的复数);
Put that another way -- of all of them who test positive -- so here they are, the individuals involved -- less than one in 100 actually have the disease. 换种方法说-- 在所有结果是患病的检测中--就是这些人-- 真正患病的几率小于1%
So even though we think the test is accurate, the important part of the story is there's another bit of information we need. 所以即便我们认为这个测试是准确的 这个例子重要的部分在于 我们还需要一些信息
Here's the key intuition. 这就是关键
What we have to do, once we know the test is positive is to weigh up the plausibility , or the likelihood , of two competing explanations. 当知道测试结果为患病时 我们要做的就是 权衡下面两种解释的概率或可能性
plausibility:n.善辩;似乎有理;貌似可信; likelihood:n.可能性,可能; competing:adj.相互冲突的;相互矛盾的;v.竞争;对抗;参加比赛;(compete的现在分词)
Each of those explanations has a likely bit and an unlikely bit. 每种解释都有一定的可能性
One explanation is that the person doesn't have the disease -- that's overwhelmingly likely, if you pick someone at random -- but the test gets it wrong, which is unlikely. 一种解释是这个人不患病-- 这种可能性比较大 如果你随机选人的话-- 但是测试结果错了 这种情况很罕见
overwhelmingly:adv.压倒性地;不可抵抗地;
The other explanation is that the person does have the disease -- that's unlikely -- but the test gets it right, which is likely. 另一种解释就是这个人不患病--这很少见-- 但测试结果正确 这可能性很大
And the number we end up with -- that number which is a little bit less than one in 100 -- is to do with how likely one of those explanations is relative to the other. 而我们最后得到的数字-- 就是略少于100的数字-- 与这几种解释之间的关联性有关
relative:adj.相对的;有关系的;成比例的;n.亲戚;相关物;[语]关系词;亲缘植物;
Each of them taken together is unlikely. 每个解释合起来都不大可能
Here's a more topical example of exactly the same thing. 这是另一个说明同样道理的例子 更加切题
topical:adj.局部的;论题的;时事问题的;局部地区的;
Those of you in Britain will know about what's become rather a celebrated case of a woman called Sally Clark, who had two babies who died suddenly. 在英国的听众知道 这是一个很有名的案子 一个女人叫做萨里?克拉克 她有两个孩子 都突然去世
Sally:n.突围;[军]出击;(感情等)迸发;俏皮话;远足;v.突围;出发;动身,外出;
And initially , it was thought that they died of what's known informally as " cot death ," 很自然人们以为这属于婴儿猝死
initially:adv.最初,首先;开头; informally:adv.非正式地;不拘礼节地; cot death:n.婴儿猝死;
and more formally as Sudden Infant Death Syndrome . 更正式的说法是婴儿猝死综合征
Infant:n.婴儿;幼儿;未成年人;adj.婴儿的;幼稚的;初期的;未成年的; Syndrome:n.[临床]综合征;综合症状;并发症状;校验子;并发位;
For various reasons, she was later charged with murder. 由于多种原因 萨里后来以谋杀罪被逮捕
And at the trial, her trial, a very distinguished pediatrician gave evidence that the chance of two cot deaths, innocent deaths, in a family like hers -- which was professional and non-smoking -- was one in 73 million. 在法庭上 一个非常著名的小儿科医师作证 两个婴儿猝死 在一个像萨里的家里-- 有经验并不吸烟的--概率为七千三百万分之一
pediatrician:n.儿科医师(等于pediatrist); evidence:n.证据,证明;迹象;明显;v.证明; innocent:adj.无辜的;无罪的;无知的;n.天真的人;笨蛋; professional:adj.专业的;职业的;职业性的;n.专业人员;职业运动员; non-smoking:adj.不抽烟的;禁止吸烟的;
To cut a long story short, she was convicted at the time. 长话短说 她最后被判有罪
convicted:v.定罪;宣判…有罪;(convict的过去式和过去分词)
Later, and fairly recently, acquitted on appeal -- in fact, on the second appeal. 后来 最近 她在上诉中无罪释放了
acquitted:v.宣判…无罪;表现好(或坏等);(acquit的过去式和过去分词) appeal:n.上诉;吸引力;申诉;魅力;v.上诉;呼吁;申诉;恳求;
And just to set it in context , you can imagine how awful it is for someone to have lost one child, and then two, if they're innocent, to be convicted of murdering them. 当置于实际情境中 大家就能想象 一个人失去了一个孩子 然后又失去了另一个 然后又被诬为凶手 这是多么可怕的事情
context:n.环境;上下文;来龙去脉;
To be put through the stress of the trial, convicted of murdering them -- and to spend time in a women's prison, where all the other prisoners think you killed your children -- is a really awful thing to happen to someone. 要被迫承受审判的压力 并判有罪-- 在女监里熬过一段日子 那里所有的囚犯 都认为是你杀了孩子--这件事发生在一个人身上真是太可怕了
put through:v.接通;完成;使穿过;使从事,使经受;
And it happened in large part here because the expert got the statistics horribly wrong, in two different ways. 而这些事的发生 很大程度上是因为那个专家 得出的数据是错误的 错误出在两方面
horribly:adv.可怕地;让人吃惊
So where did he get the one in 73 million number? 那么他是怎样得出七千三百万分之一这个数字的呢
He looked at some research, which said the chance of one cot death in a family like Sally Clark's is about one in eight and a half thousand. 他看了一些研究 那些研究上说一个家庭里一个婴儿猝死的概率 就像萨里?克拉克家 这概率是八千五百分之一
So he said, "I'll assume that if you have one cot death in a family, the chance of a second child dying from cot death aren't changed." 所以他说:“我假设如果一个家庭中出现了一个婴儿猝死 那么第二个婴儿发生猝死的概率也不会变。”
assume:v.承担;假定;采取;呈现;
So that's what statisticians would call an assumption of independence . 这被统计学家们称为独立事件
assumption:n.假定;设想;担任;采取; independence:n.独立;独立性;自恃心;独立不羁的精神;
It's like saying, "If you toss a coin and get a head the first time, that won't affect the chance of getting a head the second time." 这就像是在说:“如果你掷硬币第一次是正 这并不会影响第二次投掷得到正的概率。”
So if you toss a coin twice, the chance of getting a head twice are a half -- that's the chance the first time -- times a half -- the chance a second time. 所以如果你扔两次硬币 第一次正的几率是二分之一 第二次正的几率也是二分之一
So he said, "Here, let's assume-- 所以他说:“我们来假设
I'll assume that these events are independent . 假设这些事件是独立的
independent:adj.独立的; n.无党派议员(或候选人等);
When you multiply eight and a half thousand together twice, you get about 73 million." 当你将八千五百分之一相乘 你就会得到七千三百分之一
multiply:vt.乘; vi.乘; v.多样地; adj.多层的;
And none of this was stated to the court as an assumption or presented to the jury that way. 而上面这些并没有在法庭上向陪审团 展示作为前提
jury:n.[法]陪审团;评判委员会;adj.应急的;
Unfortunately here -- and, really, regrettably-- first of all , in a situation like this you'd have to verify it empirically . 不幸的是--确实很令人遗憾-- 首先 在这种情况下要先以经验判断
Unfortunately:adv.不幸地; first of all:adv.首先; verify:vt.核实;查证; empirically:adv.以经验为主地;
And secondly, it's palpably false. 第二 这可能是错的
palpably:可触之地;易觉察地
There are lots and lots of things that we don't know about sudden infant deaths. 我们对婴儿猝死综合症有太多不了解
It might well be that there are environmental factors that we're not aware of, and it's pretty likely to be the case that there are genetic factors we're not aware of. 很可能有一些我们并不知道的环境因素 也很可能是有一些 我们并不了解的基因因素
factors:n.因素(factor的复数); v.做代理商;
So if a family suffer from one cot death, you'd put them in a high-risk group. 所以如果一个家庭出现一个婴儿猝死 你就要把他们放到高概率组
high-risk:adj.高危险度的;
They've probably got these environmental risk factors and/or genetic risk factors we don't know about. 他们很可能有这些环境因素 和/或基因因素 而我们对这些并不知情
And to argue, then, that the chance of a second death is as if you didn't know that information is really silly. 而就像不知道上面得出的信息一样 确定第二个死亡的概率 是非常愚蠢的
It's worse than silly -- it's really bad science. 这比愚蠢还糟--这是坏科学
Nonetheless , that's how it was presented, and at trial nobody even argued it. 但是 这推论就这样呈现在法庭上 而几乎没有人质疑
Nonetheless:adv.尽管如此,但是;
That's the first problem. 这是第一个问题
The second problem is, what does the number of one in 73 million mean? 第二个问题是 七千三百万分之一这个数字意味着什么
So after Sally Clark was convicted -- you can imagine, it made rather a splash in the press -- one of the journalists from one of Britain's more reputable newspapers wrote that what the expert had said was, "The chance that she was innocent was one in 73 million." 在萨里?克拉克被定罪后-- 可以想象 这在媒体中引起轩然大波-- 一个英国相当有名望的报社记者写到 这个专家说 “她无罪的几率是七千三百万分之一”
splash:v.溅,泼;用...使液体飞溅;n.飞溅的水;污点;卖弄; journalists:n.新闻记者(journalist的复数); reputable:adj.声誉好的;受尊敬的;卓越的;
Now, that's a logical error. 这是一个逻辑上的错误
logical:adj.合逻辑的,合理的;逻辑学的;
It's exactly the same logical error as the logical error of thinking that after the disease test, which is 99 percent accurate, the chance of having the disease is 99 percent. 这个错误相当于认为 在准确率99%的疾病测试后 患病的几率是99%
In the disease example, we had to bear in mind two things, one of which was the possibility that the test got it right or not. 在疾病的例子中 我们要注意两点 一个是这个测试得出的可能性是否正确
bear in mind:vi.记住;考虑到;
And the other one was the chance, a priori , that the person had the disease or not. 另一个就是这个人本身是否患病
priori:adj.先验的;优先的(等于apriori);adv.先验地(等于apriori);
It's exactly the same in this context. 这个情形是完全相同的
There are two things involved -- two parts to the explanation. 这个解释包括两个部分
We want to know how likely, or relatively how likely, two different explanations are. 我们想知道这两种不同解释发生的可能性 或相对的可能性
relatively:adv.相当程度上;相当地;相对地;
One of them is that Sally Clark was innocent -- which is, a priori, overwhelmingly likely -- most mothers don't kill their children. 一个是 萨里?克拉克是清白的-- 也就是 一个先验 极为可能-- 大多母亲不会杀自己的孩子
And the second part of the explanation is that she suffered an incredibly unlikely event. 这个解释的第二部分 就是她遭遇了一个可能性极小的时间
incredibly:adv.难以置信地;非常地;
Not as unlikely as one in 73 million, but nonetheless rather unlikely. 不像七千三百万分之一那样小 但也同样不可能
The other explanation is that she was guilty . 另一个解释就是
guilty:adj.有罪的;内疚的;
Now, we probably think a priori that's unlikely. 我们可能认为一个先验是 不大可能
And we certainly should think in the context of a criminal trial that that's unlikely, because of the presumption of innocence . 然后我们当然应该认为在刑事审判的情形下 这是不大可能的 因为我们以无罪为前提
presumption:n.放肆,傲慢;推测; innocence:n.清白,无罪;天真无邪;
And then if she were trying to kill the children, she succeeded. 如果她那时试着杀害孩子 那么她成功了
So the chance that she's innocent isn't one in 73 million. 所以她无罪的机率并不是七千三百万分之一
We don't know what it is. 我们不知道这个个机率是多少
It has to do with weighing up the strength of the other evidence against her and the statistical evidence. 这同衡量其它对她不利的证据 和数据型证据有关
We know the children died. 我们知道 孩子死了
What matters is how likely or unlikely, relative to each other the two explanations are. 重要的是这两种解释 相对发生的机率
And they're both implausible . 他们都令人难以置信
implausible:adj.难以置信的,不像真实的;
There's a situation where errors in statistics had really profound and really unfortunate consequences . 在这种情形下 错误的数据 产生了很重大而且不幸的结果
profound:adj.深厚的;意义深远的;渊博的; consequences:n.后果,结果;影响(consequence的复数);
In fact, there are two other women who were convicted on the basis of the evidence of this pediatrician, who have subsequently been released on appeal. 事实上 还有其他两个女人因这个小儿科医师的作证 而被定罪 而她们在上诉中都被无罪释放了
on the basis of:根据;基于…; subsequently:adv.随后,其后;后来; released:v.释放;使免除;已发布;(release的过去分词和过去式)
Many cases were reviewed . 很多案子都因此而重审
reviewed:v.复习;评估;评论;检讨;(review的过去分词形式)
And it's particularly topical because he's currently facing a disrepute charge at Britain's General Medical Council . 这引起了很高的关注 因为他正面临着 英国综合医学委员会的名誉调查
currently:adv.当前;一般地; disrepute:n.不光彩,坏名声; Council:n.(市、郡等的)政务委员会;市政(或地方管理)服务机构;
So just to conclude -- what are the take-home messages from this? 总结一下 我们应该得到什么警示呢
conclude:v.断定:得出结论:终止:达成:缔结(协定) take-home:=take-homepay;
Well, we know that randomness, and uncertainty, and chance are very much a part of our everyday life. 我们知道 随机性、不确定性和概率 在生活中影响重大
It's also true -- and, although, you, as a collective , are very special in many ways, you're completely typical in not getting the examples I gave right. 并且大家作为一个集体 在很多方面都很特别 大家没有回答正确我给出的例子 是完全正常并具有代表性的
collective:adj.集体的;共同的;集合的;集体主义的;n.集团;集合体;集合名词; typical:adj.典型的;特有的;象征性的;
It's very well-documented that people get things wrong. 有很多人们理解错误的记录
well-documented:adj.证据充分的;
They make errors of logic in reasoning with uncertainty. 他们在不确定性方面犯逻辑错误
We can cope with the subtleties of language brilliantly -- and there are interesting evolutionary questions about how we got here. 我们可以很好地解决语言的细微差别 还有有趣的进化方面的问题 如我们是怎么来到这里的
cope:v.处理;n.大圆衣; subtleties:n.微妙;阴险;敏锐(subtlety的复数); brilliantly:adv.灿烂地;辉煌地;光亮地; evolutionary:adj.进化的;发展的;渐进的;
We are not good at reasoning with uncertainty. 我们并不擅长不确定性
That's an issue in our everyday lives. 这是我们生活中的一个问题
As you've heard from many of the talks, statistics underpins an enormous amount of research in science -- in social science , in medicine and indeed, quite a lot of industry. 像你们听过的很多演讲 数据是很多科学研究中 的基础--社会科学 医学 确实 很多行业
underpins:v.加强,巩固,构成;加固(墙)基;(underpin的第三人称单数) social science:n.社会科学;社会科学学科;
All of quality control , which has had a major impact on industrial processing , is underpinned by statistics. 所有的质量控制 这些对工业过程的影响极其重要 这些都以数据为基础
quality control:n.质量控制; impact:n.影响;效果;碰撞;冲击力;v.挤入,压紧;撞击;对…产生影响; industrial:adj.工业的,产业的; n.工业股票; processing:v.加工;处理;审核;数据处理;v.列队行进;缓缓前进;(process的现在分词) underpinned:vt.巩固;支持;从下面支撑;加强…的基础;
It's something we're bad at doing. 而这方面我们并不擅长
At the very least, we should recognize that, and we tend not to. 至少我们应该意识到这一点 并尽力防止错误发生
recognize:v.认识;认出;辨别出;承认;意识到;
To go back to the legal context, at the Sally Clark trial all of the lawyers just accepted what the expert said. 回到法律方面 在萨里?克拉克的案子中 所有律师都接受了专家的证词
legal:adj.法律的;合法的;法定的;
So if a pediatrician had come out and said to a jury, "I know how to build bridges . I've built one down the road . 如果一个小儿科医师出来对陪审团作证 我不知道怎样建造桥梁 我在路那边建了一个
build bridges:建立桥梁;构建桥梁;建立纽带; down the road:只要沿着这条路;将来;在路上;
Please drive your car home over it," 开车回家的时候请放心过桥
they would have said, "Well, pediatricians don't know how to build bridges. 他们会说 小儿科医师不懂怎样建造桥梁
pediatricians:n.儿科医师;[儿科]儿科医生(pediatrician的复数);
That's what engineers do." 那是工程师的工作
On the other hand , he came out and effectively said, or implied , "I know how to reason with uncertainty. I know how to do statistics." 而另一方面 他们站出来说 或暗示 我知道怎样运用不确定性 我知道怎样处理数据
On the other hand:另一方面; implied:adj.不言而喻的; v.含有…的意思; (imply的过去分词和过去式)
And everyone said, "Well, that's fine. He's an expert." 然后大家都说 这没问题 他是专家
So we need to understand where our competence is and isn't. 所以我们应该明白我们的什么是我们的强项 什么不是
competence:n.能力,胜任;权限;作证能力;足以过舒适生活的收入;
Exactly the same kinds of issues arose in the early days of DNA profiling , when scientists, and lawyers and in some cases judges, routinely misrepresented evidence. 完全相同类型的问题每天都出现在DNA的测绘中 科学家 律师 有些情况下甚至法官 都会错误地解释证据
arose:vi.出现(arise的过去式);引发; early days:初期;为时尚早;前期; profiling:n.资料搜集;v.扼要介绍;概述;写简介;(profile的现在分词) routinely:adv.例行公事地;老一套地; misrepresented:adj.不如实叙述的;v.不如实地叙述(misrepresent的过去式);
Usually -- one hopes -- innocently , but misrepresented evidence. 通常--大家希望--结果是无罪 只是错误地解释了证据
innocently:adv.纯洁地;无罪地;
Forensic scientists said, "The chance that this guy's innocent is one in three million. 法庭上的科学家说 这个人无罪的机率是三百万分之一
Forensic:adj.法院的;辩论的;适于法庭的;
Even if you believe the number, just like the 73 million to one, that's not what it meant. 即使你相信这个数据 就像七千三百万分之一 这也并不是它真正的含义
And there have been celebrated appeal cases in Britain and elsewhere because of that. 因为这个在英国和其他地方 有很多上诉案件
elsewhere:adv.在别处;到别处;
And just to finish in the context of the legal system. 这就是在法律层面上我们要考虑的问题
It's all very well to say, "Let's do our best to present the evidence." 说“我们尽量给予证据更好的解释”固然很好
But more and more, in cases of DNA profiling -- this is another one -- we expect juries , who are ordinary people -- and it's documented they're very bad at this -- we expect juries to be able to cope with the sorts of reasoning that goes on. 但越来越的地 在DNA测绘中--这也很重要-- 我们希望陪审团 那些普通人-- 记录表明他们非常不擅此类-- 我们希望陪审团能够处理好这些推理
juries:n.[法]陪审团(jury的复数);评委会;
In other spheres of life, if people argued -- well, except possibly for politics . 在生活的其它方面 如果人们在争辩的时候--当然 也许不包括政治
spheres:n.[数]球体(sphere的复数); v.把…放在球体内(sphere的第三人称单数形式); politics:n.政治;钩心斗角;政治观点;v.(贬)从事政治活动;(politic的第三人称单数)
But in other spheres of life, if people argued illogically, we'd say that's not a good thing. 但是在生活的其他方面 如果人们争辩地并不合逻辑 我们认为这不是好现象
We sort of expect it of politicians and don't hope for much more. 在不确定性方面 我们也从某种程度上对政客抱有希望
politicians:n.政治家;(蔑)政客;(美)政治贩;(politician的复数)
In the case of uncertainty, we get it wrong all the time -- and at the very least, we should be aware of that. 但并不奢求什么 我们一直都没对过 至少 我们应该认识到这一点
And ideally , we might try and do something about it. 并且 希望我们能试着做什么去改变这一点
ideally:adv.理想地;观念上地;
Thanks very much. 谢谢大家